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OFFICIAL PAGE:  Isola Pro FX

Isola Pro FX, now up to version 3.1, is a VST / VST3 plugin from Lakeside Audio for both macOS and Windows which performs audio source separation in real time. The developer, Markus Heininger, indicates that the best results can be had while using the MIDI mode which helps guide the source separation. According to the developer, unlike many other products using simple left and right channel subtraction or phase/invert filter methods, the underlying algorithm works in real time by using psychoacoustic analysis. A demo version is available and full details are available at the above link.